CASE REPORT: HEPATOCELLULAR CARCINOMA IN A PATIENT WITH PYRIDOXAMINE 5-PHOSPHATE OXIDASE (PNPO) DEFICIENCY UNDERGOING PYRIDOXAL 5-PHOSPHATE (PLP) TREATMENT

Pyridoxamine 5-phosphate oxidase Antennas (PNPO) deficiency is an autosomal recessive inborn error of metabolism that typically manifests as seizures resistant to conventional anticonvulsants, often presenting in the neonatal period to early infancy.One of the main treatments, pyridoxal 5-phosphate (PLP), carry a risk of liver toxicity.Concerns abo

Background: Compared to efficacy research, studies investigating the processes of change in psychological therapy are rare, especially for internet-based interventions.While many online therapies are based on face-to-face therapy protocols, it is unknown whether the processes of clinical improvement differ between these treatment formats.Objective: